Combined indeterminate and impaired glucose tolerance is a novel group at high risk of Cystic Fibrosis-related Diabetes.

Abstract

BACKGROUND\nIndeterminate (INDET) and impaired glucose tolerance (IGT) are independently associated with CFRD risk. We determined whether patients meeting both criteria have increased risk of diabetes in two separate adult cohorts.\n\n\nMETHODS\nThe Montreal CF (MCFC; n=293 baseline & 198 for prospective analysis excluding subjects identified with incident CFRD at baseline) and Lyon CF (DIAMUCO; n=144/105) are prospective observational cohorts.\n\n\nRESULTS\nIn the MCFC and DIAMUCO, mean age was (25.5 ± 7.7 & 25.0 ± 8.6 years), BMI (21.7 ± 3.0 & 20.2 ± 2.2\xa0kg/m 2), FEV1% of (73.2 ± 22.1 & 62.5 ± 21.9%) and follow-up (6.9 ± 3.8 & 2.4 ± 1.2 years), respectively. In the MCFC cohort, the IGT only and INDET+IGT groups had greater risk of CFRD (p = 0.0109). In the DIAMUCO cohort, there was lower diabetes-free survival in the INDET+IGT group (p = 0.0105). In both cohorts, CFRD risk ranged from 17% in NGT patients up to 42 to 56% in patients with combined INDET and IGT.\n\n\nCONCLUSION\nConclusion: Patients who meet combined criteria have a higher risk of developing diabetes probably justifying closer follow-up.