The British journal of radiology | 2019
Automated CT registration tool improves sensitivity to change in ventricular volume in patients with shunts and drains.
Abstract
OBJECTIVE\nComputerized tomography (CT) is the mainstay imaging modality for assessing change in ventricular volume in patients with ventricular shunts or external ventricular drains (EVDs). We evaluated the performance of a novel fully automated CT registration and subtraction method to improve reader accuracy and confidence compared with standard CT.\n\n\nMETHODS\nIn a retrospective evaluation of 49 ventricular shunt or EVD patients who underwent sequential head CT scans with an automated CT registration tool (CT CoPilot), three readers were assessed on their ability to discern change in ventricular volume between scans using standard axial CT images versus reformats and subtraction images generated by the registration tool. The inter rater reliability among the readers was calculated using an intra class correlation coefficient (ICC). Bland-Altman tests were performed to determine reader performance compared to semi-quantitative assessment using the bifrontal horn and third ventricular width. McNemar s test was used to determine whether the use of the registration tool increased the reader s level of confidence.\n\n\nRESULTS\nInter rater reliability was higher when using the output of the registration tool (single measure intraclass coefficient [ICC] of 0.909 with versus 0.755 without the tool). Agreement between the readers assessment of ventricular volume change and the quantitative assessment improved with the registration tool (limits of agreement 4.1 vs 4.3). Furthermore, the tool improved reader confidence in determining increased or decreased ventricular volume (p < 0.001).\n\n\nCONCLUSION\nAutomated CT registration and subtraction improves the reader s ability to detect change in ventricular volume between sequential scans in patients with ventricular shunts or EVDs.\n\n\nADVANCES IN KNOWLEDGE\nOur automated CT registration and subtraction method may serve as a promising generalizable tool for accurate assessment of change in ventricular volume, which can significantly affect clinical management.