A Case Report of IgG4-related Diseases Involving Mammary Gland, Parotid Gland and Orbit

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is a chronic progressive autoimmune disease. Mammary gland, parotid gland and orbit involvement in IgG4-RD is extremely rare. Herein, we report a case of IgG4-RD presenting with pain in breasts, parotid masses and bilateral exophthalmos. A 52-year-old woman came to our breast disease clinic for treatment, because of pain in her breasts. After examination, eliminated the possibility of breast cancer. Physical examination indicated bilateral parotid hypertrophy and a small amount of clear liquid flowed out while pressed lightly, space-occupying lesions in the upper and outer orbits of the both eyes, this condition had been existing for 6 years. The results of immunohistochemical staining indicated IgG4-positive plasma cells in parotid masses and laboratory tests revealed elevated serum IgG4 (1480 mg/dL, normal range: 3-201 mg/dL), a diagnosis of IgG4-RD of the mammary gland, parotid gland and orbit was formulated.