Cluster analysis of uric acid exchange parameters in female rats

Abstract

Background. Uric acid is traditionally considered as the final product of human and primate DNA/RNA degradation, devoid of useful physiological activity. However, there is an opinion that the uric acid molecule, by analogy with methylxanthines (caffeine, theophylin, theobromine) has physiological activity. The acquired experience allows us to offer a topic for future research: “Neurotropic and immunotropic activity of endogenous uric acid”. Working hypothesis. Uric acid, interacting with A1 and A2a adenosine receptors as well as phosphodiesterase and Na,K-ATPase of neurons, modulates the activity of nerve centers, which in turn modulate immunocytes. Perhaps the direct effect of uric acid on immunocytes, since the existence of theophylline-resistant and theophylline-sensitive subpopulations of Tlymphocytes has long been known. The proposed article is the first swallow of the announced project. Material and Methods. Experiment was performed on 58 healthy female Wistar rats 220-300 g. Among them 10 animals remained intact, using tap water from drinking ad libitum. The rats of others groups for 6 days administered through the tube various fluids at a dose of 1,5 mL/100 g of body mass. The day after the completion of the drinking course the plasma