Efectos en la salud asociados a la ingesta de frutas cítricas en infantes de 6 a 24 meses de edad: Protocolo de una revisión sistemática

Abstract

Introduction: In Latin America, the recommendations about the introduction of citrus in the complementary feeding are heterogeneous. Food restriction during the first years of life can increase the risk of nutritional deficiencies. The objective of the review is to identify the health effects associated with the citrus intake in infants from 6 to 24 months of age.Material and Methods: We will include studies with preterm infants, without diseases or surgical interventions that require dietary modification. Citrus are considered as Orange, Camu Camu, Tangelo, Lemon, Mandarin, Lime, Cider, Grapefruit, and Clementine, consumed in the natural form or in juices or extracts, or in combination with other foods. All health effects associated with the intake of citrus will be reported. The databases of MEDLINE (through PubMed), Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), Epistemonikos, LILACS, and SciELO will be searched.Also, grey literature will be searched in international thesis repositories. Observational studies, randomized and non-randomized clinical trials will be included. Study selection, data extraction and risk of bias assessment will be done independently, in duplicate and with blinding. At the end of each stage, blinding will be lifted to resolve conflicts between reviewers through consensus. A narrative synthesis of the results of the primary studies and the risk of bias will be conducted.Ethics and Dissemination: The protocol is registered in PROSPERO: CRD42021230561.