Annual Cervical Cancer Screening Revealed Early Stage Clear Cell Adenocarcinoma of the Uterine Cervix: A Case Report

Abstract

Clear cell adenocarcinoma of the uterine cervix (CCAC) is rare. We describe a case of CCAC, which was treated with complete resection without adjuvant therapy. The patient was a 42-year-old woman, who had no chief complaint. She had undergone annual cervical cancer screening, and no abnormalities had been detected in previous examinations. However, in a subsequent screening examination, cervical cytology produced negative results, but cervicovaginal erosion was observed at the uterine cervix. A detailed examination led to adenocarcinoma being suspected, and so conization was performed, resulting in a diagnosis of CCAC. A microscopic examination revealed atypical cells with clear-slightly basophilic cytoplasm, and immunohistochemical studies showed that they were positive for napsin A, p16, and AE1/3. Radical hysterectomy, pelvic lymph node dissection, and bilateral salpingo-oophorectomy were performed. Complete resection was achieved, and the postoperative diagnosis was CCAC, pT1b1N0M0, ly(-), v(-). The patient did not undergo adjuvant treatment. She is still alive and recurrence-free. J Clin Gynecol Obstet. 2019;8(1):21-24 doi: https://doi.org/10.14740/jcgo530