The Epidemiology of Extremity Threat and Amputation Following Vasopressor-dependent Sepsis.

Abstract

RATIONALE\nExtremity threat and amputation following sepsis is a well-publicized and devastating event. However, there is a paucity of data exists surrounding theabout the epidemiology of extmreityextremity threat following sepsis onset.\n\n\nOBJECTIVES\nWe aim toTo estimate the incidence of extremity threat with or without surgical amputation in community sepsis.\n\n\nMETHODS\nMultihospital Rretrospective cohort study of adults with Sepsis-3 hospitalized at XX14 academic and community sites from 2013 to 2017. Vasopressor-dependent sepsis was identified by administration epinephrine, norepinephrine, phenylephrine, vasopressin, or dopamine for >1 hour during the 48 hours before to 24 hours following sepsis onset. Outcomes included the incidence of extremity threat, defined as acute onset ischemia, with or without amputation in the 90 days following sepsis onset. The association between extremity threat, and demographics, comorbid conditions, and, and time-varying sepsis treatment factorss were evaluated using a Cox-proportional hazards model.\n\n\nRESULTS\nAmong 24,365 adults with sepsis, 12,060 (54%) were vasopressor-dependent (mean±standard deviation SD age, 64±16 years; male, 6,548 [54%]; sequential organ failure assessment (SOFA), 10±4). Of these, 231 (2%) patients had a threatened extremity with 26 undergoing 37 amputations, a risk of 2.2 (95% CI: 1.4-3.2) per 1,000, and 205 not undergoing amputation, a risk of 17.0 (95% CI: 14.8-19.5) per 1,000. 95% of the total 37Most amputations occurred in lower extremities (95%), a median (interquartile range) of 16 (6.3-4039.9) days after sepsis onset. Compared to patients with no extremity threat, patients with threat had a higher sequential organ failure assessmentSOFA score (11±4 vs 10±4; P < 0.001), serum lactate (4.6 mmol/L [2.4-8.7] vs 3.1 [1.7-6.0]; P < 0.001), and more bacteremia (n = 37 [37%??] vs n = 2,087 [26%]; P < 0.001) at sepsis onset. Peripheral vascular disease, congestive heart failure, sequential organ failure assessmentSOFA score, and norepinephrine equivalents were significantly associated with the risk of extremity threat.\n\n\nCONCLUSIONS\nThe evaluation of a threatened extremity resulting in surgical amputation occurred in 2 per 1,000 patients with vasopressor-dependent sepsis.