Correlation of HOMA-IR with BMI-for-age percentile in children and adolescents from the Soconusco region of Chiapas, Mexico

Abstract

espanolIntroduccion. La resistencia a la insulina es un factor importante en el desarrollo de diabetes mellitus tipo 2 y de enfermedades cardiovasculares. En pediatria, su morbimortalidad resalta la importancia diagnostica con fines de atencion primaria. Objetivo. Determinar los valores del homeostatic model assessment insulin resistance (HOMA-IR) y su relacion con el indice de masa corporal percentil (IMCp) en ninos y adolescentes de la region Soconusco, Chiapas. Materiales y metodos. Estudio transversal. Se determino sobrepeso y obesidad por IMCp en 112 pacientes pediatricos (5-19 anos); se determinaron concentraciones de glucosa y de insulina serica para estimar el HOMA-IR. Resultados. Se encontro una prevalencia combinada de obesidad y sobrepeso de 66% con valores de insulina (p=0.010) y de HOMA-IR (p=0.015) mas elevados que los del grupo de peso normal. El HOMA-IR se correlaciono positivamente con la edad (r=0.636), el peso (r=0.569), la talla (r=0.578) y el IMCp (r=0.198). Conclusion. En la poblacion de estudio, el HOMA-IR presenta una correlacion moderadamente significativa con el aumento del IMCp. EnglishIntroduction: Insulin resistance (IR) is a major risk factor for developing diabetes mellitus type 2 and cardiovascular diseases. In pediatrics, morbidity and mortality associated with these diseases highlights the diagnostic importance of IR for primary care. Objective: To determine Homeostatic Model Assessment Insulin Resistance (HOMA-IR) values and their correlation with BMI-for-age percentile in children and adolescents of the Soconusco region of Chiapas, Mexico. Materials and methods: Cross-sectional study. Overweight and obesity prevalence was determined based on the Body Mass Index (BMI) percentile of 112 children (5-19 years old). Glucose and fasting insulin values were quantified and used for estimation of HOMA-IR. Results: The combined prevalence of obesity and overweight was 66%, with insulin (p=0.010) and HOMA-IR (p=0.015) values higher than those of the normal weight group. The HOMA-IR values correlated positively with age (r=0.636), weight (r=0.569), height (r=0.578) and BMI percentile (r=0.198). Conclusions: In the study population, HOMA-IR has a moderately significant correlation with an increase in BMI percentile.