IDENTIFICATION OF MUTATIONS OF RESISTANCE TO FLUOROQUINOLONES, AMINOGLYCOSIDES AND ETHAMBUTOL IN RIFAMPICIN-RESISTANT MYCOBACTERIUM TUBERCULOSIS

Abstract

proposed an alternative explanation: POA is primarily active against PanD but PanD is only essential if the bacteria are expressing a stringent response, the other genes associated with resistance in some way disrupt the stringent response and eliminate the sensitive phenotype. This suggests a critical role for the stringent response in the life cycle of M. tuberculosis as compounds are being developed that target this pathway we suggest these compounds are particularly promising compounds for the treatment of tuberculosis.