[Significance of CT perfusion examination of cerebral blood flow for assessing the risk of brain ischemia in patients with intracranial arterial aneurysm ruptures].

Abstract

Prognosing the outcome of cerebral ischemia in the acute SAH phase still remains the topical issue for clinical practice because this largely affects the choice of an optimal timing of aneurysm clipping. The traditional criteria are often not effective enough to predict changes in cerebral ischemia, especially in patients in a compensated or subcompensated state who often develop delayed ischemia, which may lead to serious complications. The introduction of a CT perfusion technique for evaluating the volumetric cerebral blood flow stimulated the development of a new stage in investigation of cerebral ischemia in non-traumatic SAH.\n\n\nPURPOSE\nThe study purpose was to evaluate the significance of cerebral blood flow indicators obtained by CT perfusion for prediction of delayed cerebral ischemia and postoperative ischemic complications to optimize treatment of patients with ruptures of intracranial arterial aneurysms.\n\n\nMATERIAL AND METHODS\nThe study included 70 patients who underwent aneurysm clipping and 42 non-operated patients. The inclusion criteria were as follows: WFNS grade I-III condition, vasospasm according to transcranial Doppler sonography, and availability of CT scans, including CT perfusion data. The vasospasm severity and perfusion indicators _(rCBV and MTT) were evaluated. The severity of subarachnoid and ventricular hemorrhage was evaluated according to the A. Hijdra method. The final results were evaluated using a clinical-statistical method, including ROC analysis.\n\n\nRESULTS\nAn analysis of the obtained data revealed that the risk of delayed cerebral ischemia and postoperative ischemia increases significantly if the baseline hemispheric CBF value is below a threshold of 40 ml/100 g/min, and the baseline MMT indicator is above a threshold of 5 s. There was asymmetry of these CT perfusion indicators due to a larger deviation from the threshold values in the homolateral hemisphere compared to the opposite side. The ROC analysis results demonstrated diagnostic sensitivity and diagnostic specificity of the CT perfusion technique.\n\n\nCONCLUSION\nThe CT perfusion data together with the SAH severity and localization indicators may be used as predictors for the cerebral ischemia outcome in choosing the optimal timing of aneurysm clipping during the acute SAH period in patients in a WFNS grade I-III condition and with signs of mild or moderate vasospasm.