T-cell malignancies pathogenesis, a system hematology/oncology

Abstract

Human T-cell leukemia/lymphoma is one of the most aggressive hematologic malignancy, which associated with poor prognosis. T-cell prolymphocytic leukemia (TPLL), Sezary syndrome, and acute T cell lymphocytic leukemia (T-ALL) are included to T-cell neoplasm. It is important to understand the alteration among expression of the genes toward malignant T cells. For acquiring more insights in oncogenesis molecular events, the systems hematology analysis was done. At first, the differentially expressed genes (DEGs) were taken pairwise among the four sample sets of T-PLL .vs normal T-cell, Sezary syndrome .vs normal T-cell, and ATLL .vs normal T-cell. Then, the protein-protein interaction networks (PPINs) were reconstructed via using the hub genes. Finally, the pathways of cells proliferation and transformation were identified TPLL and Sezary syndrome and ATLL.