POLYMORPHISM OF INTERLEUKIN 10 IN PATIENTS WITH AN IRRITABLE BOWEL SYNDROME DEPENDING ON PSYCHOPATHOLOGICAL DISORDERS

Abstract

Irritable bowel syndrome, which is a common functional intestinal disorder, can be attributed to psychosomatic pathology, since it contains all three characteristic features of this group of diseases. The study assessed discrimination in the distribution of alleles and genotypes -1082G/A, 819C/T, -592C/A IL-10 in groups of patients with IBS with various psychopathological disorders. The peculiarities of the distribution of alleles and genotypes formed by the polymorphic site -592C/A IL-10 were identified. For groups of patients with “IBS with anxiety disorders” and “IBS with depressive syndrome”, the frequencies of the rare allele and its heterozygous genotype -592C/A were increased. According to the criterion of the odds ratio, prognostic significance was an increase in the carrier frequency only in the group of patients “IBS with anxiety disorders” (OR = 3.9, 95% CI 1.3–12.5). It has been established that the polymorphism -592C/A of the IL-10 gene was associated with the variant “IBS with anxiety disorders”.