Psödoeksfoliasyon ve aköz hümörde matriks metalloproteinaz-2 düzeyi

Abstract

Purpose: The aim of this study was to investigate the metalloproteinase-2 (MMP-2) levels in aqueous humor of patients with primary open-angle glaucoma (POAG), pseudoexfoliation syndrome (PES) and pseudoexfoliative glaucoma (PEG) . Materials and Methods: In this prospective study, MMP-2 levels were measured by immunoassay ELISA method in humorous aqueous samples taken from 117 eyes of 97 patients with PES, PEG, PAAG cases and cataract cases in the control group (CG). Each group was compared with the control group and each other. Results: The mean total MMP-2 levels detected in aqueous humor were 56.69 ± 51.3 ng / ml in the CG,\xa0 97.84 ± 81.12 ng / ml in the PES group, 108.00 ± 83.7 ng / ml in the PEG group and 83.89 ± 71.68 ng / ml in the POAG group. Despite the high levels of MMP-2 in the PES, PEG and POAG groups compared with the CG, there was no statistically significant difference for mean MMP-2 levels in aqueous humor between the PES, PEG and PAAG groups. Conclusion: In our study it was found that the mean MMP-2 levels were higher in the PE groups than both CG and POAG group. However, there was no statistically significant difference between the PE group and the POAG group. It has been concluded that the distruption of the MMP-2 turnover may be one of the important mechanisms in PEM accumulation in cases with PE and plays an important role in the IOP increase.