Antiinflamatuvar İlaçlardan Asemetasin′in UV-dedektörlü Akışa Enjeksiyon Analiz Tekniğiyle Miktar Tayini

Abstract

In this study, a flow-injection analysis (FIA) system with UV-detection is described for the direct determination of Acemetacin, which is antiinflammatory-analgesic drug used for the treatment of rheumatic diseases. The best suitable carrier solvent system was found to be 2 mM NaOH prepared in ethanol :water (20:80, v/v). Using a flow-rate of 1,2 mL min -1 and wavelength of 280,8 nm, the linear response was obtained for Acemetacin in the range of 1,2×10 -5 ‒5,8×10 -5 M (5,0‒24,1 μg mL -1 ) with a detection limit of 1,6×10 -6 M (0,7 μg mL -1 ). The proposed method was successfully applied to the determination of Acemetacin in commercial capsules and results were compared by a simple UV-spectrophotometric method developed in this study.