Effects of calcium-vitamin D and metformin on the menstrual cycle and ovulation in polycystic ovary syndrome patients in a tertiary care teaching hospital

Abstract

Polycystic ovary syndrome (PCOS) is one of the common causes of infertility in women and it affects 6-10% of reproductive age. The adverse clinical features of PCOS include irregularities in menstrual cycles, androgen excess symptoms, fat deposition and obesity. Simply by looking at the number of polycystic ovaries or clinical manifestations of hyperandrogenism, studies which focus on pregnancy as a primary outcome with anovulation as the identifying symptom has good clinical impact. Regular menstrual cycles and hyperandrogenism women are at higher risk of insulin resistance as compared with irregular menstrual cycles and chronic hyperandrogenism and/or polycystic ovary disease.