International Surgery Journal | 2019
Single dose prophylactic antibiotic before surgery to prevent surgical site infection: a prospective interventional study
Abstract
Antibiotics play a particularly important role in the postoperative care of patients undergoing elective surgery because of the high incidence of surgical site infection (SSI). It has been reported that 30-40% of patients experience post-operative SSI when a prophylactic antibiotic is not administered. Although several recent studies have indicated that single-dose (SD) administration may be as effective as multiple-dose, controversy still exists concerning the frequency and appropriate combination of antibiotics. In adults of all ages, SSIs represent a significant financial burden and are associated with increased length of hospitalization, readmission, and mortality. It has been reported that patients who develop SSIs have a mortality rate that is 211 times higher than that of patients who do not develop SSIs, and the mortality rate for SSIs is up to 6%. Preventative measures in the preoperative period have changed rapidly over the past few decades. A large volume of research has established the importance of a host of preventative measures in the operative period. Examples include skin decontamination, perioperative warming, and antimicrobial prophylaxis. Surgical antibiotic prophylaxis given at induction of anesthesia is recommended for any surgery apart from clean ABSTRACT