The association between laboratory risk indicator for necrotizing fasciitis score with clinical signs and symptoms of necrotizing fasciitis: a retrospective study

Abstract

Necrotizing fasciitis (NF) is a fulminating soft tissue infection, generally caused by virulent bacteria producing toxins. It encompasses simple pyoderma to life threating Infection varying according to anatomical location, tissue involvement and offending organism. Earliest record of necrotizing fasciitis was described by Baurienne, who in 1764 described progressive soft tissue necrotizing gangrene of male genitalia. It was 1 described by Jones in 1871 and coined it as hospital gangrene. It is associated with a fulminant course and high mortality. These infections are characterized by rapidly progressive inflammation and necrosis. Clinical course of the infection process is influenced by the virulence of the microbes and of the inoculum, complicating even the most minor elective or emergency procedures for trauma. Deep fascia is the primary site of pathology but subsequently Fasciia and muscles get involved. Early local symptoms pain, erythema, swelling, skin color changes, bronzed skin and Induration. Crepitation is present in case of infection by gas producing organism. ABSTRACT