Risk of bleeding after plasmapheresis!

Abstract

Plasmapheresis is a procedure in which extracorporeal separation of blood component results in a filtered plasma product via centrifugation or the use of semipermeable membranes. Plasmapharesis is used when a toxic substance as immunoglobulin present in the plasma and so can be removed. It is considered as first line therapy for different diseases including the renal and non-renal diseases. Some of the renal causes for plasmapharesis are renal transplant rejection that is antibody-mediated, Goodpasture’s syndrome, Recurrent focal segmental glomerular sclerosis, and catastrophic antiphospholipid syndrome. Some of the neurological disorders that need plasmapharesis as acute Guillain–Barré syndrome, Chronic inflammatory demyelinating polyneuropathy, Myasthenia gravis and paraproteinaemias associated Polyneuropathy. Metabolic indication as Familial hypercholesteremia. Microvascular angiopathy as Thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome. The replaced fluid during plasma exchange include albumin, electrolyte solutions, hydroxyethyl starch, FFP, and purified protein products such as individual clotting factors or antithrombin III. Albumin is the most commonly used replacement fluid as it has low side-effect widely available. the selection of the replaced fluid depends on the underlying disease, associated disorders, certain laboratory markers (exampleABSTRACT