A rare case of aggressive invasive fungal sinusitis with multidrug resistant Pseudomonas aeruginosa co-infection in immunocompromised: a therapeutic challenge

Abstract

Antibiotic drug resistance has become a worldwide health risk, as the development of antibiotics is now being outpaced by expeditious emergence of resistance. Multidrug resistance in bacteria can broadly be either due to accumulation of multiple genes, each coding for resistance to a single drug or by increased expression of genes that code for multidrug efflux pumps. In addition, a perplexing array of microorganisms in an immunocompromised patient creates a diagnostic and therapeutic dilemma for the clinician. To effectively diagnose and manage these infections in such immunocompromised host, a prior knowledge of which host defect predispose to specific infections must be known.