Biochemical analysis of serum amylase and lipase in patients with type 2 diabetes mellitus

Abstract

Introduction: Diabetes mellitus is a metabolic disease characterized by abnormally high blood glucose levels. Caused by a derangement in the secretion and function of the endocrinal portion of the pancreas as there is a interrelation between the functional and the anatomical portion of the pancreas. Objectives: To evaluate serum amylase and serum lipase in diabetic patients and its association. Materials and Methods: 30 age and sex matched diagnosed cases of type 2 DM between 40-80yr were included in the study and 30 healthy individuals as controls. All samples were analyzed by auto analyser. Data analysis was done by means of two tailed and independent ‘t’ test. Results: There was a considerable decline in serum amylase (p<0.0001) and serum lipase (p=0.00661) in diabetic patients compared to controls who were age and sex matched. FBS showed moderate positive correlation with serum amylase (r=0.1086) and serum lipase (r=0.0155). Conclusion: The current study shows an pancreatic exocrine destruction in type 2 DM. Serum pancreatic enzymes can be used as an extra explanatory parameter for the evaluation of progression of the disease and response to treatment.