Comparison of the level of lipid peroxidative marker and antioxidants between preeclamptic and normotensive pregnant women

Abstract

Background: Preeclampsia is a complex multisystem disorder that is characterized by hypertension and proteinuria which is exclusively seen in human species. This disorder is a leading cause of maternal and fetal morbidity and mortality. It is seen that placental oxidative stress is involved in the etiopathogenesis of preeclampsia. This oxidative stress induces endothelial cell injury which in turn causes lipid peroxidation. Although the lipid peroxidation is counteracted by the action of several antioxidants.\nThe aim of this study was to elucidate the changes in the level of lipid peroxidation markers and antioxidants in preeclamptic pregnant women that may contribute to the pathogenesis in preeclampsia.\nMaterials and Methods: Fifty (50) pregnant women clinically diagnosed as preeclampsia were taken as subjects and an equal number of age matched, parity matched and gestation age matched healthy normotensive pregnant women were taken as controls for the study. This is the case-control hospital based study carried in the Department of Biochemistry, Pacific Institute of Medical Sciences (PIMS), Umarda, Udaipur (Raj.).Blood samples collected were estimated for Malondialdehyde (MDA) and Superoxide dismutase (SOD) using standard spectrophotometric method and Vitamin C and Uric acid using standard colorimetric method. Comparison between both the groups was done by Student’s t-test.\nResults: The levels of MDA and uric acid were significantly elevated (p\nConclusions: The results of our study concluded that the increased levels of lipid peroxidation product (MDA) and depletion of antioxidant such as Vitamin C and SOD except uric acid in preeclamptic women may suggest that oxidative stress plays a key role in inducing oxidative stress and expression of preeclampsia.\n\n\nKeywords : Preeclampsia, Lipid perodixation, Oxidative stress, MDA, SOD, Vitamin C, Uric acid.