Archive | 2019
Characterization of a more clinically relevant human leukemia xenograft model to examine perturbation of MET/SAM metabolism as a novel therapeutic paradigm for MLL-R leukemia in vivo.
Abstract
.......................................................................................................v-vi LIST OF FIGURES..............................................................................................viii CHAPTER 1: INTRODUCTION AND BACKGROUND..........................................1 CHAPTER 2: ESTABLISHING A MORE CLINICALLY RELEVANT MOUSE MODEL OF PATIENT AML AND STANDARD OF CARE CHEMOTHERAPY, TO INVESTIGATE THE THERAPEUTIC POTENTIAL OF ALTERATIONS TO MET/SAM METABOLISM ...................................................................................36 CHAPTER 3: DYSREGULATION OF MET/SAM METABOLISM REGULATE DOT1L EXPRESSION AND FUNCTION; A NOVEL VULNERABILITY IN MLL-FP LEUKEMIA...........................................................................................................62 CHAPTER 4: OVERALL DISCUSSION AND SUMMARY...................................95 STRENTHS AND LIMITATIONS.......................................................................103 FUTURE DIRECTIONS.....................................................................................107 REFERENCES..................................................................................................111 ABBREVIATIONS..............................................................................................121 CURRICULUM VITAE.......................................................................................123