Influence of polypropylene mesh on local and systemic production of cytokines during thoracoplasty in experiment

Abstract

Introduction. The question of the body s immune reactivity when using mesh implants for plastic surgery of the chest frame remains not fully understood.Aims. The effect of the polypropylene mesh endoprosthesis Surgipro on systemic and local cytokine production after reconstruction of the chest frame was evaluated.Materials and methods. The work was performed on male Wistar rats weighing 250 50 grams (n=21). The main group consisted of rats with musculo-aponeurotic plasty (n=9), the comparison group consisted of animals that underwent chest plasty after removal of the posterior segment of the IV rib measuring 1.0 cm and overlapping over the mesh (n=9). Healthy rats without surgery served as control (n=3). The animals were taken out of the experiment on days 1, 10 and 30 after the operation. Determination of cytokines TNF-, IFN- and IL-10 in the blood serum and biopsy of the postoperative scar was performed by the method of enzyme-linked immunosorbent assay.Results. It was found that in the experiment, the plastic of the chest frame affects the systemic and local production of cytokines TNF-, IFN- and IL-10. A more intense increase in serum and local anti-inflammatory cytokines was recorded with the use of the implant (p˃0.05). At the same time, the production of anti-inflammatory IL-10 was recorded at values below the control (p˃0.05).Conclusions. The conducted experimental study revealed that the use of a mesh endoprosthesis in the restoration of a defect in the thoracic frame causes more pronounced systemic and local production of cytokines TNF-, IFN- and reduces the production of IL-10.