Investigation on the Sensitivity and Specificity of Lipid Profile in the Second Trimester in the Incidence of Preeclampsia in Women Referring to Beheshti and Al-Zahra Hospitals during the Years of 2016 and 2017

Abstract

Introduction: Preeclampsia is described as a systemic disorder and leads to a potentially life threatening disease. The evidences show that stress oxidative of lipid profile is effective in the pathogenesis of Preeclampsia. In this study, specificity and sensitivity of lipid profile as a predictive factor in the incidence of preeclampsia was studied. \nMethods: This study was a cohort study that conducted on pregnant women referring to hospitals from 2016 to 2017. In this study, 244 prim gravid women with normal blood pressure in the weeks of 16-18 were included and a lipid profile test wasrequested. Finally, it was followed the cases for the incidence of preeclampsia till the end of pregnancy. In this study, the SPSS 20 software was utilized. Moreover, the Chi-Square, Covariance and independent t tests was run. \nResults: During this study, 16 cases developed preeclampsia. In preeclamptic cases it was found considerable changes in lipid profile such as significant increase in LDL and TC, and significant decrease in HDL (P-value < 0.001). Likewise, it was not found considerable changes in TG (P-value=0.21). Furthermore, TC with sensitivity of 68.8 % and specificity of 69.6 %, LDL with sensitivity 75 % and specificity of 75.8 % and HDL with sensitivity of 76.2 % and specificity of 75 % were reported. \nConclusion: The findings in our study suggested that cases that developed preeclampsia had disturbed lipid profile and the best predictive factors are HDL, LDL and TC, respectively.