A comparison between the effects of metformin and N-acetyl cysteine (NAC) on some metabolic and endocrine characteristics of women with polycystic ovarian syndrome

Abstract

1 M.D (Obst. & Gynae.), Assistant Professor, Department of Obstetrics & Gynaecology, Nalanda Medical College, Patna, Bihar, India 2 M.D (Obst. & Gynae.), 2 nd yr. PG student, Department of Obstetrics & Gynaecology, Nalanda Medical College, Patna, Bihar, India *Corresponding Author Dr Neena Agrawal Assistant Professor, Department of Obstetrics & Gynaecology, Nalanda Medical College, Patna, Bihar, India Abstract Objective: To compare N-acetyl cysteine (NAC) with metformin on polycystic ovary syndrome (PCOS). Method: Study was performed in two groups by randomized double blind clinical trial, in women with diagnosed PCOS without additional complication. In one group oral NAC 600mg, three times a day and in other group oral metformin 500mg, three times a day was prescribed for 24 weeks duration. After completion of this duration of treatment Fasting blood glucose (FBS), insulin, lipid profile, Homeostasis model assessment (HOMA) index were measured. The entire blood sample was taken in fasting state and was compared in two groups. Result: Fifty women in NAC group and fifty women in metformin group finished the study. High-density lipoprotein was higher in NAC group. Conclusion: NAC can improve lipid profile and fasting blood sugar and fasting blood insulin better than metformin.