A Study of Coronary Risk and LDL in Type II Diabetic Patients

Abstract

A prospective study was carried out to find the percentage of dyslipidemia in type II diabetics in comparison with non diabetic individuals, to study the pattern of dyslipidemia, categorize the levels of LDL, HDL and triglycerides into higher, borderline and lower risk of developing coronary heart disease in type II diabetics and categorize the type of and level of dyslipidemia in symptomatic and asymptomatic coronary artery disease. Introduction In newly diagnosed, middle-aged patients with type 2 diabetes, the same group found that the incidence of cardiovascular mortality increased with rising fasting plasma glucose (FPG) at baseline during a 10-year study. In all patients, irrespective of treatment mode this association was found. A high FPG level significantly predicted cardiovascular mortality independent of other risk factors in multiple regression analysis 19 . As hyperglycemia alone does not explain all the increased risk for CHD in people with type 2 diabetes, other factors must be considered. It has been postulated that rather than being a complication of DM, CHD and DM share common genetic and environmental antecedents. They have in common many CHD risk factors, and a possible link between them is insulin resistance syndrome. Compared with the non diabetic population the prevalence of dyslipidemia, obesity and sedentary lifestyle is higher in people with type 2 diabetes. People with diabetes tend to have higher lowdensity lipoprotein (LDL) cholesterol and triglycerides and lower HDL. In them LDL particles tend to be smaller and denser, and this increases the risk for atherosclerosis. Even at concentrations well below the National Cholesterol Education Program target of 130 mg/dl, LDL cholesterol is a strong independent predictor of coronary heart disease in individuals with diabetes, even when components of diabetic dyslipidemia are present. These results support recent recommendations for aggressive control of LDL, cholesterol in diabetic individuals, with a target level of <100 mg/dl. 21 www.jmscr.igmpublication.org Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v7i3.219