Retrospective Comparative Study of Clinical Outcome of X ray Based Versus Computed Tomography Based Treatment Planning in Conventional Radiotherapy in Carcinoma Cervix

Abstract

Introduction: In conventional radiotherapy of carcinoma cervix treatment planning can be done by X ray simulation or CT simulation. Objectives: To analyze whether CT simulation can provide better treatment outcome in carcinoma cervix. Methods: 182 patients of carcinoma cervix treated in our institute in the time period 2010-2011 and matched the inclusion criteria of study (age between 50 to 65 years, stage IIA to IIIB, has taken minimum 3 cycle of concurrent chemotherapy) was analysed for their clinical outcome in terms of treatment failure, distant metastasis, loco regional recurrence, residual disease. Results: CT based planning showed better treatment outcome in terms of less distance mets, residual disease, loco regional recurrence and improved disease-free survival and overall survival. Conclusion: CT based radiotherapy planning has improved clinical outcome in case of carcinoma cervix. So CT based radiotherapy planning is a good option for carcinoma cervix patient who do not afford 3D CRT. Introduction In the state of Bihar in India, most of the cervical cancer patients are from low socioeconomic status and are of advanced stage. In advanced stages of disease proper nodal coverage is needed to prevent treatment failure. Most of these patients of Ca cervix are not affording for 3DCRT (3 Dimensional Conformal Radio Therapy) or IMRT (Intensity modulated Radio Therapy) and are being treated in our hospital by conventional X ray based radiotherapy. For curative treatment for locally advanced carcinoma cervix the gross disease and the tissue at potential risk of disease spread along with pelvic nodes should be irradiated properly. Conventional X ray based radiotherapy treatment planning is based on bony landmarks. So soft tissue cannot be assessed in this radiotherapy technique. To overcome this limitation conformal radiotherapy technique based on CT (Computer Tomography) scan or MRI (Magnetic Resonance Imaging) is used. By this technique proper target delineation can be done and normal tissue can be spared from irradiation accordingly. Hence more precise treatment can be given. In developed countries 3DCRT and IMRT is increasingly used now a days. [1] Objectives To analyze whether CT based planning in conventional radiotherapy can provide better www.jmscr.igmpublication.org Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v7i3.232