Clinicopathological Study of Malignant Melanoma at Tertiary Care CentreSMS Medical Collage, Jaipur

Abstract

Introduction: Malignant melanoma is a type of skin cancer which is arises from the pigment-producing cells melanocytes. Malignant Melanomas typically occur in the skin but rarely occur in the mouth, intestines or eye (uveal melanoma). Also may occur anywhere on the body. Symptoms of malignant melanoma include a new, unusual growth or a change in an pre-existing mole. Treatment may involve surgical excision, radiation, medication or in some cases, chemotherapy. Objectives: To document the pattern of clinico-pathological spectrum of malignant melanoma cases at SMS Medical college, Jaipur. Methods: The present study was a retrospective study conducted in SMS Medical college, department of pathology, Jaipur between 2013 to 2019. During this period total 90 cases received and diagnosed on biopsy. Results: We received 90 cases in our department with age range from 10 to 86 years. M: F ratio was 1.2:1 with male predominance. Most common age group is 51-60 year. In our study melanoma are predominantly non cutaneous origin (53) like rectum followed by anal canal, nasal-sinonasal, oral cavity and lymph node, followed by cutaneous melanoma (37). Majority of histologic subtype of melanoma are nodular melanoma 17 (45.9%) followed superficial spreading melanoma 13(35.1) then acrolantigeeous 7(18.9). Half (50%) of the excisional biopsies were at Clark’s level III. Conclusion: Malignant melanoma is aggressive tumor, more common in male then female. Nodular melanoma and superficial spreading was commonest histologic type malignant melanoma in our population. Keyword: malignant melanoma, nodular, Clark’s level. Introduction Malignant melanoma, which develop from the melanocytes, is an important disease entity as it causes majority (75%) of deaths related to skin cancer. (1) Malignant melanoma (MM) is a potentially lethal and aggressive tumor of melanocytic origin. it comprises only 3% of all skin cancers diagnosed every year, it accounts for approximately 75% of all skin cancer-related deaths. (2) http://jmscr.igmpublication.org/home/ ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v9i5.06