Status of Oxidative stress in the Patient of primary open angle glaucoma with type-2 Diabetes mellitus

Abstract

Introduction: Primary open-angle glaucoma (POAG) is a chronic and age-related disease that is the leading cause of irreversible visual disability. Primary open-angle glaucoma is known to be associated with diabetes mellitus (DM) type 2 and hypertension. Glaucoma is a progressive optic neuropathy and is the leading cause of blindness in the developing and industrialized countries. Aim and Objective: Assessment of antioxidant enzyme in Type-2 Diabetes mellitus primary open angle glaucoma patients, diabetes without Primary open-angle glaucoma as compared to normal controls. Material and Methods: A total of 100 patients, 100 Type-2 Diabetes mellitus Primary open-angle glaucoma patients from the last one year and 100 normal healthy individuals were chosen as a control group. Results: The mean values of FBS, were significantly increased (P<0.001) in type -2 Diabetes mellitus Primary open-angle glaucoma, diabetes without Primary open-angle glaucoma cases as compared to normal healthy individuals. significantly decreased levels of antioxidant enzyme activity (SOD, CAT, GPx) levels in Type-2 DM with Primary open angle glaucoma, Diabetes without (POAG) as compared to the controls groups (p<0.001).