Anti-mullerian Hormone as a Diagnostic Marker of Polycystic Ovarian Syndrome in a Tertiary Care Centre in Eastern India

Abstract

1 Senior Resident, Department of Endocrinology and Metabolism 2 Assistant Professor, Department of Endocrinology and Metabolism, 3 Associate Professor & Head of the Department, Department of Endocrinology and Metabolism 4 Professor & ExHead of the Department, Department of Endocrinology and Metabolism *Corresponding Author Dr Anirban Sinha Assistant Professor, Department of Endocrinology and Metabolism Abstract: Introduction: It has been posited that elevated AMH due to follicular excess, rather than facilitating ovulation, plays a critical role in the arrest of follicular growth that is characteristic of PCOS. Since 2003, the diagnostic criteria for PCOS particularly TVS which have problem with acceptance included an assessment of the follicular pool by specific ultrasound findings. There is support for the notion that AMH serves as a surrogate marker for the antral follicle count in the diagnosis of PCOS. Aims: Anti-mullerian hormone level in the polycystic ovarian syndrome and it association with clinical parameters. Material and Method: observational Cross-sectional study carried out in the department of Endocrinology and metabolism, Medical College, Kolkata from march 2017 to January 2019.Total number of study subjects were 207 out of which 138 were cases. Results: The mean AMH were significantly higher in the case as compare to control group with a value of 11.15±4.6 ng/ml and 3.68±2.09 ng/ml respectively. The Spearman s rank (rho) correlation of Anti – mullerian Hormone with ovarian morphology and AMH is strongly and significantly associated with ovarian volume (r = 0.506, p<0.00) and follicular number ( r= 0.0582, p <0.001 ) case group. ROC curve of the AMH: ROC curve was drawn to determined the cut-off of AMH in our PCOS population showed the cut-off AMH > 5.06 ng/ml with the sensitivity & specificity of 97.8% and 80.4% respectively.