Correlation of Clinicopathological Features of Breast Cancer with Its Intrinsic Subtypes

Abstract

Background: Estrogen receptor (ER), Progesterone receptor (PR) and Her2Neu expression status have important roles in prognosis and treatment of breast cancer. This study aims at correlating clinical and pathological features of breast cancer patients with its intrinsic subtypes. Methods: 100 patients of breast cancer undergoing modified radical mastectomy were selected for the study. Four subtypes based on immunohistochemistry evaluated ER/PR/HER2 status, clinicopathological features, and prognosis were analyzed retrospectively and statistically. Results: The following distribution was observed : luminal A subtype (ER+, PR+, Her2neu-) – 34 cases, luminal B subtype (ER+,PR+, Her2Neu+) -13 cases, Her2neu enriched (ER-, PR-, Her2Neu++)20 cases, basal subtype(triple negative)-33 cases. The clinical features like age, menarche age, parity, years of lactation and presence of risk factors were strongly correlated to breast cancer intrinsic subtypes (p <0.05) while pathological factors like proliferative index is strongly correlated to breast cancer intrinsic subtypes(p<0.05). Conclusion: Breast cancer intrinsic subtypes are associated with its clinical and pathological features. This association can be helpful in treatment modification of patients with long term follow up. Study also shows the importance of NPI as a correct prognostic indicator and guide for planning adjuvant therapy that uses tumor size, nodal status and tumor grade. Introduction Cancer of the breast in women is a major health burden worldwide. It is the most common cause of cancer among women in both high-resource and low-resource settings, and is responsible for over one million of the estimated 10 million neoplasms diagnosed worldwide each year in both sexes. [1] Breast cancer is the most common diagnosed malignancy in women worldwide (22%) and in India (18.5%) it ranks second to cervical cancer. The burden of breast cancer is increasing in both developed and developing countries; the peak occurrence of breast cancer in developed countries is above the age of 50 whereas in India it is above the age of 40. [2] Clinicopathological Features Clinico-pathologic features of breast cancer includes age at diagnosis, menopausal status, mean size of breast lump , presence of signs and symptoms, association with any risk factors, www.jmscr.igmpublication.org Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v7i2.16