Role of Vitamin C in Prevention of Preeclampsia in High-Risk Cases: Randomized Controlled Trial

Abstract

OBJECTIVE To evaluate the effect of vitamin C intake on the incidence of preeclampsia in high-risk cases. METHODOLOGY Prospective double-blinded multi-center randomized controlled trial involving 940 qualified patients equally divided into two groups one receiving vitamin C and the other receiving placebo starting from 12 weeks gestational age. RESULTS No significant difference was found between vitamin C and placebo on the incidence of preeclampsia, maternal problems (prelabor rupture of membranes, antepartum hemorrhage, and placental abruption), and fetal outcomes (birth weight, Apgar scores, preterm delivery, admission to NICU, and low birth weight). CONCLUSION Vitamin C intake in pregnancy is not recommended for prevention of preeclampsia, maternal or fetal problems in cases at high-risk for developing preeclampsia.