Study of antidiabetic activities of endophytic fungi isolated from plants

Abstract

Diabetes mellitus, a metabolic disorder, is one of the major causes of death among all health issues. Diabetes can be regulated by antidiabetic drugs that control the activity of some metabolic enzymes including amylases. Endophytic fungi have the potential to prevent diabetes through inhibition of alpha-amylase activity. This study was aimed to isolate and evaluate endophytic fungi from different plants like Mango (Mangifera indica) coded as MAN, MBR, Neem (Azadirachta indica) indicated as NGU and NTH and jambolan (Syzygium cumini L) shown as JCO, JGR, JGY for their antidiabetic potentials. Eight endophytic fungi, isolated from the leaves of these plants, were screened for their potential anti-amylase activity. Aqueous extract of endophytic fungi isolated from jambolana (200μg/ml) exhibited significant amylase inhibition (62%) followed by MAN, MBR, NGU and NTH sample (49-59%). Therefore, endophytic fungi from the leaves of selected plants might be remarkable sources of discovering natural anti-diabetic molecules. Keyword: Azadirachta indica; Diabetes mellitus; Mangifera indica; Syzygium cumin