PHARMACOKINETICS OF ANTI-BACTERIAL PREPARATIONS IN CYSTIC FIBROSIS IN CHILDREN

Abstract

Cystic fibrosis (CF) is one of the most frequent hereditary multisystem disease. Pathogenesis of lung damage includes development of chronic microbialinflammatory process on the background of severe violation of mucociliary clearance. Proper and timely antibiotic therapy of infectious process determines the disease prognosis greatly. To select an effective antibacterial drugs dosing regimen, it is necessary to take into account pathophysiological features of cystic fibrosis, which determine the unique pharmacokinetics (PK) in this category of patients. The review describes significant effect of age on such PK processes as: absorption, distribution, biotransformation, and elimination. The influence of factors affecting pharmacokinetics of antibacterial drugs in cystic fibrosis in childhood (transit through digestive tube, state of biliary system, biotransformation processes, etc.) is disclosed. Studying pharmacokinetics of antibacterial drugs in children with CF will increase the effectiveness of treatment, reduce the risks of antibiotic resistance, and improve the overall prognosis.