The function of the heart after successful transcatheter mitral valve repair due to severe functional regurgitation.

Abstract

INTRODUCTION\nThe function of the heart after successful transcatheter edge-to-edge mitral valve repair (TMVR) remains not fully investigated.\n\n\nOBJECTIVES\nThe aim of our study was to assess the direct impact of effective TMVR on the strains of the left atrium (LA) and the left (LV) and right (RV) ventricles in patients with functional mitral regurgitation (FMR) due to a coronary artery disease (CAD) or dilated cardiomyopathy.\n\n\nPATIENTS AND METHODS\nOut of a group that successfully underwent TMVR we selected twenty-eight for analysis. The remodeling of the LA, LV, RV and their strains were assessed.\n\n\nRESULTS\nIn the short-term follow-up, we found a positive change of the LA s and LV s volumes, RV s dimensions but not the LV ejection fraction (LV-EF). No improvements of strains were observed in pre/post analysis of LV-s, RV-s and LA-s and LA-s Phase 3. We found a deterioration of LA-s Phase 1 and Phase 2 strains in patients with paroxysmal atrial fibrillation (AF) history: LA-s Phase 1 2.5 (5.47 - 0) P=0.01; LA-s Phase 2 2.2 (-0.82 - 5.47) vs P=0.049 and CAD: LA-s Phase 1 -3.1 (-0.75 - -6.61) P=0.004; LA-s Phase 2 (-3.7 - -7.48) P=0.01.\n\n\nCONCLUSIONS\nOur data indicates that no improvement of heart strains can be expected after successful TMVR in the short-term follow-up, while the function of the LA may even deteriorate in some subpopulations.