Isolation and Characterization of Nicotine Reducing Probiotics

Abstract

Nicotine, 3-(1-methyl-2-pyrrolidinyl) pyridine is an alkaloid found in the nightshade Solanaceae family of plants, predominantly in the leaves of tobacco and it is a colorless, less to pale yellow, hygroscopic oily liquid (Hossain and Salehuddin, 2013). People can smoke, chew or sniff tobacco. Smoked tobacco products include cigarettes, cigars, bidis and kretes and chewed tobacco products include chewing tobacco, snuff, dip and snus; snuff can also be sniffed (NIDA, 2018). Nicotine is an addictive substance that can lead to nicotine dependence and addictive behaviour in human populations (Niu et al., 2000). Nicotine can cause cancer, gene mutation & malformation (Yildiz, 2004) and neurotoxin developmental effects of nicotine can naturally affect a variety of cellular processes such as generation of oxidative radicals, apoptosis and hyperplasia of cell, enhancing gene expression to secrete hormones and regulation of enzymatic activity (Yildiz, 2004; Yildiz et al., 1998; Qiao et al., 2005 and Gurusamy and Natarajan, 2013).