Capsular Typing of Cap5k and Cap8k Genes in S. aureus Isolates from Wound Samples of Cattle

Abstract

Capsular polysaccharides (CP) produce by Staphylococcus aureus play an important role in its colonization, pathogenesis and confer resistance to phagocytosis by masking of surface proteins, the typical antigens that trigger an adaptive immune response and prolong its persistence in the bloodstream of the host (Keinhörster et al., 2019). Many bacterial species have been shown to produce CP, and a single species can produce numerous, structurally distinct CP, forming a basis for serotyping isolates (Visansirikul et al., 2020). Of the 11 capsular polysaccharides types, the majority of the human and animal staphylococci are of cap5 and cap8 genotypes (O Riordan and Lee, 2004; Verdier et al., 2007). S. aureus strains which produce a high amount of capsular polysaccharides are relatively more resistant to nonspecific opsonophagocytic killing indicating that encapsulation might be an important immune evasion strategy for the organism (Nanra et International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 10 Number 02 (2021) Journal homepage: http://www.ijcmas.com