EFEK PAPARAN KADMIUM (Cd) TERHADAP FUNGSI GINJAL PEKERJA BENGKEL LAS

Abstract

ABSTRACT \nCadmium is one of the heavy metals that has nephroxic effect and \xa0dangerous to \xa0human health, especially welding workers. If cadmium enters the body will bind to metallotionein protein.\xa0 This process can increase the formation of free radical compounds, thereby induced lipid peroxidation which damage kidney organ and may cause impaired the renal function. Decreased renal function is characterized by an increase of β2-Microglobulin and creatinine level. The aim of this study are to know effect of Cd exposure to renal function indicated by increasing of Cd, creatinine and β2-M level. Research design used case control. Research subjects consist of thirty welding workers in Purwokerto with a period of working more than 3 years as case subjects and control subjects come from Pamijen village Baturaden. \xa0Data of Cd, creatinine and β2-M level were analyzed by t independent. Result of this research showed that in case subjects occur an increase of Cd, creatinine and β2-M level and have higher level compare with control subjects.It can be concluded that Cd exposure has an effect on renal disfunction which indicated by increasing\xa0 blood Cd level, creatinine and β2-M level.