The expression and prognostic value of ischemia modified albumin (IMA), red blood cell distribution width (RDW), and lipoprotein (LP) in patients with diabetes mellitus complicated with coronary heart disease.

Abstract

BACKGROUND\nThis study explored the levels and prognostic value of ischemia modified albumin (IMA), red blood cell distribution width (RDW), and lipoprotein (LP) in patients with diabetes melltus (DM) complicated withcoronary heart disease (CHD).\n\n\nMETHODS\nA total of 95 patients with DM who were diagnosed and treatedfrom January 2018 to January 2019 were retrospectively analyzed. All included patients underwent percutaneous coronary intervention (PCI). Patients with DM complicated with CHDwere designated group A (n=61) and patients without CHD complications were designated group B (n=34). During the same period, 45 patients without DM who underwent physical examination in our hospital were included as a control group.The levels of IMA, LP, and RDW in the 3 groups of patients were compared. The study examined the occurrence of cardiovascular events after PCI treatment in patients with DM complicated with CHD, and the related risk factors were assessed using multivariate logistic regression analysis. Furthermore, the receiver operating characteristic (ROC) curve was used to analyze the value of IMA, LP, and RDW in predicting cardiovascular events in DM patients complicated with CHD.\n\n\nRESULTS\nThe levels of IMA, LP, and RDW werehigher in groups A and B compared to the control group (P<0.05). In patients who experienced a cardiovascular event, the levels of IMA, LP, and RDW were higher than those observed in patients who did not experience a cardiovascular event (P<0.05). The area under the ROC curve of IMA, LP, RDW, and the combination of the three factors for the prediction of cardiovascular events were 0.910, 0.774, 0.846, and 0.995, respectively. The combined detection of the 3 factors showed the best predictive value.Patients with abnormal values in blood lipids, blood creatinine, IMA, LP, and RDW had a significantly poorer prognosis in terms of adverse cardiovascular events (P<0.05). The unconditional multivariate logistic regression model showed that abnormal levels of blood creatinine, IMA, LP, and RDW were independent risk factors for cardiovascular events in patients with DM complicated with CHD after PCI treatment (P<0.05).\n\n\nCONCLUSIONS\nThe levels of IMA, RDW, and LP wereincreased in patients with DM complicated with CHD. Furthermore, abnormal levels of IMA, LP, and RDW are independent risk factors that affect cardiovascular events in these patients following PCI treatment. The combined detection of all three indicators may be an effective means to predict the prognosis of these patients.