Sleep-Disordered Breathing (SDB) In Pituitary Adenomas: Preliminary Report.

Abstract

\n Sleep-disordered breathing (SDB) and obstructive sleep apnea (OSA) are atypical presentation of pituitary adenomas secreting adrenocorticotropic hormone (ACTH) and growth hormone (GH). However, the non-secreting adenomas may cause alterations of sleep architecture. Objective: The aim of the study was to evaluate clinical and sleep characteristics of OSA in a group of patients with functioning (FPA) and non-functioning pituitary adenomas (NFPA). Methods: We analyzed 6 patients with SDB and pituitary adenoma during 3 years. SDB were studied by means of overnight polysomnographic study in our sleep lab. Results: SDB were documented in 6 patients (3 M, mean age 50.8 years and mean BMI 35), with pituitary adenoma. In acromegalic patient was found a worsening of sleep parameters (AH index 18.4; AH index supine 29.6; OD index 12.7), successfully treated with CPAP therapy. Conclusion:Our data show that in patients with pituitary adenoma, SDB should be better investigated. Expert consultation and a multidisciplinary approach to sleep disordered are needed in patients with pituitary adenoma.