Archive | 2021
BCL-xL is Correlated With Disease Severity in Neonatal Infants With Sepsis
Abstract
\n Objective: to investigate the association between disease severity in patients with sepsis and TNF-a, B cell lymphoma-extra-large (BCL-xL), and serum Mitochondrial membrane potential (MMP). Methods: we investigated the correlation between SNAP-II score and levels of TNF-α, BCL-xL, and MMP-index, respectively. The receiver-operating characteristics (ROC) was to assess the diagnostic value of the the Bcl - xL in the diagnosis of the of septic shock. Results: A total of 37 children were diagnosed with sepsis. SNAP-II was positively correlated with the level of BCL-xL (r=0.450, P\u2009=0.006). The area under the BCL-xL curve was 83.0%, and the 95% CI was 67.1–93.3%. The septic shock threshold was >3.022 ng/mL, and the sensitivity and specificity were 75.0% and 95.2%, respectively. The positive predictive value was 92.3%, and the negative predictive value was 83.3%. Furthermore, the level of SNAP-II was >10, and BCL-xL was >3.022 ng/mL as the threshold, and the sensitivity, specificity, positive predictive value, and negative predictive value of septic shock were 93.8%, 95.2%, 93.8%, and 95.2%, respectively. Conclusion: A correlation has been established between SNAP II and neonatal prognosis. The combination of BCL-xL and SNAP-II was more sensitive and specific than the BCL-xL to predict neonatal sepsis outcomes.