Lifestyle & Behavioral Change Interventions among Prostate Cancer Men on Androgen Deprivation Therapy: Protocol for A Systematic Review.

Abstract

\n Background: Androgen deprivation therapy (ADT) is one of the main treatment modalities for men with prostate cancer, It is known to relieve symptoms in patients with metastatic prostate cancer and might have a survival benefit in some patients. Despite the potential benefits associated with its use, ADT can cause a multitude of side effects that adversely affect quality of life. We will be discussing the potential benefits of lifestyle modifications including smoking cessation, moderating alcohol and caffeine consumption, vitamin D and calcium supplementation, and regular incorporation of weight bearing or resistance exercises, nutritional and dietary modifications and the role of food supplementation. We will also investigate the role and efficacy of Social Cognitive Theory in empowering and motivating patients to promote adherence to those lifestyle modifications.Methods: A literature search was conducted on PubMed, Scopus and the Cochrane Library a total of 2455 publications was found. The search was made to include lifestyle interventions among prostate cancer patients on androgen deprivation therapy.Conclusions: The review will investigate if there is benefit in implementing lifestyle interventions as smoking cessation, moderating alcohol, food supplementation, phyto-nutrients supplementation and regular weight bearing or resistance exercises to mitigate side effects of androgen deprivation therapy. We will also investigate behavioral interventions using social cognitive theory to maintain adherence to those lifestyle modifications using patient education.Systematic review registration: It was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 28/4/2020 and was last updated on 2/2/2020 (registration number 167663).