Case Series: Refractory Cases of Hyper-serum IgE Achieve Transformative Decrease by TCM Therapy

Abstract

\n Background:Chronic conditions from IgE-mediated hypersensitivity reactions affect over 150 million Americans, but affordable and effective treatment options remain largely unavailable to the pediatric population. Traditional Chinese medicine has been shown to reduce IgE levels in refractory cases of hyper-serum IgE and have transformative effects in pediatric patients with chronic allergic inflammation.Presentation:Here we present ten patients with chronic atopic conditions and refractory hyper-serum IgE who were treated with TCM therapy. The patients had at least two atopic conditions as well as multiple allergic sensitivities to foods and environmental allergens: all of the patients presented with food allergies (FA) and atopic dermatitis (AD), 60% of patients presented with an environmental allergy (EA), 40% of patients presented with asthma (AS), 10% had celiac disease (Celiac), and 10% had eosinophilic esophagitis (EoE). All of the affected patients had IgE levels greater than 5,000kIU/L (normal =300kIU/L) prior to treatment. None of the patients had an IgE of greater than 5,000kIUL after treatment. We treated 10 children with IgE-mediated hypersensitivity reactions using topical and oral TCM and found an average reduction of 3,723kIU/L IgE per patient (p=0.01) or 79%. Conclusion:We present a ten-patient case series on the effective lowering of hyper-serum IgE using Traditional Chinese Medicine in otherwise refractory pediatric cases of chronic atopic inflammation. TCM is an affordable and safe alternative for chronic atopic conditions compounded with hyper-serum IgE. Future research via random controlled trials should be used to test the efficacy of TCM.