WHO Grade III Anaplastic Astrocytoma In A 72 Years Old Male-A Case Report

Abstract

\n Glioma is a common type of tumor that originates in the glial cell in brain and is devastating in nature. It can affect all age groups but is more common in adults and has been found more in males than in females with a ratio of 1.3/1. Despite the aggressive treatment it relapsed and can cause mortality because of its infiltrative nature. This WHO type III Anaplastic Astrocytoma is more common in 40-50 years old with a median of 41 years. Here, we report a new case of Glioma occurring in a 72 year old male, who presented with a right sided headache, forgetful, worsening memory, behavioral problem along with increased agitation and irritability. MRI Brain WO/W revealed a mass in the left thalamus and basal ganglia region with a thick rim of peripheral enhancement. Diagnosis of Anaplastic Astrocytoma (WHO Grade III) was confirmed by histology and immunohistochemical analysis of the tumor.Conclusion:It is a case of Left sided WHO GRADE III Anaplastic astrocytoma which is rare in this age group of 72 years. The patient was managed with gamma knife radiosurgery, chemotherapy with Temozolomide (TMZ), and targeted molecular therapy with Bevacizumab. The patient improved with remission of symptoms.