Archive | 2021
The Value of MRI Dynamic Enhancement Quantitative Parameters In Distinguishing UIP And NSIP
Abstract
\n Background Interstitial pneumonia is a lung disease characterized by pulmonary interstitial inflammation and progressive pulmonary fibrosis. There are many causes of it, which lead to different types with different prognosis. Moreover, the mixture of different classifications will make the diagnosis difficult for radiologists, and it will also make treatment difficult for clinicians. Therefore, patients and clinicians urgently need new imaging methods to solve this problem. Currently, the most common types of interstitial pneumonia are usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP).The purpose of this article is to introduce the value of MRI dynamic enhancement quantitative parameters in the identification of UIP and NSIP.Methods All patients with interstitial pneumonia whose images on HRCT were consistent with UIP and patients with NSIP were further examined by dynamic enhanced MRI. Follow-up was continued. Patients with UIP confirmed by pathology or ineffective after treatment and with imaging characteristics consistent with UIP were classified as UIP group (n=9). In addition, NSIP was confirmed pathologically, or the treatment was effective and the imaging characteristics were consistent with NSIP, which was classified as another group (n=18). All patients underwent high-resolution CT plain scan and MRI plain scan + dynamic enhancement scan. Different types of interstitial pneumonia were compared to obtain the dynamic enhancement quantitative parameter values at the pathological site or the most severe level was selected for the region of interest after clinical diagnosis. (Region of interest, ROI) delineate the obtained quantitative parameter values, and then compare the quantitative parameter values of MRI dynamic enhancement in each group. Results The differences in dynamic enhancement quantitative parameters between the UIP and NSIP groups were statistically significant. Correspondingly, the pseudo-colour images formed by the lesions in these two groups were different. ktrans and iAUC values were lower in the UIP group than in the NSIP group, with p-values of 0.000 and 0.043 respectively; Kep and Ve values were not statistically different between the two groups. On the pseudo-colour map, the lesions in UIP were mainly blue - colourless, while the NSIP lesions were mainly light yellow - light blue.Conclusions The quantitative parameters of MRI dynamic enhancement examinations are considered to be valuable in identifying UIP and NSIP.