Involvement of subventricular zone shortened the survival of pediatric glioblastoma

Abstract

\n PURPOSE\n\nGlioblastoma involved with subventricular zone (SVZ) predicted a worse outcome in adult, but we know less about it based on children population due to the rarity of pediatric glioblastoma (pGBM). We performed this study to probe into the clinical and prognostic features of glioblastoma involved with SVZ in children.\nMETHODS\n\nWe selected thirty-one patients diagnosed with pediatric supratentorial glioblastoma at our department between January 2015 and January 2020. Clinical data and prognostic results were reviewed retrospectively.\nRESULTS\n\nInvolvement of SVZ was associated with larger tumor volume (p\u2009=\u20090.007), lower edema index (EI) (p\u2009=\u20090.010), passive adjuvant therapy (p\u2009=\u20090.029), worse progression-free survival (PFS) (p\u2009=\u20090.001) and overall survival (OS) (p\u2009<\u20090.001), it didn’t correlate to age, sex, preoperative KPS, extent of resection (EOR), tumor side, Ki-67, expression of P53 and ATRX and mutation of IDH1 and IDH2 genes. Independent of EOR and adjuvant therapies, involvement of SVZ was a prognostic factor of PFS and OS in pGBM.\nCONCLUSION\n\nInvolvement of SVZ was an independent prognostic factor of PFS and OS in pGBM, and it associated with large volume, mild edema and passive adjuvant therapy. More research should be developed to optimize the treatment strategy of pGBM involved with SVZ.