Retinal Nerve Fibre Layer and Ophthalmic Artery Blood Parameters in Pseudoexfoliation Syndrome and Pseudoexfoliative Glaucoma

Abstract

\n PurposeThis study investigates the relationship between ophthalmic artery blood flow parameters and retinal nerve fiber layer (RNFL) thickness in eyes with pseudoexfoliation. MethodsThree comparisons were made in this study. In the first, eyes without glaucoma with pseudoexfoliation in any of the eyes were compared with the control group. In the second, eyes with pseudoexfoliation and without glaucoma were compared with those with pseudoexfoliation and glaucoma. In the third, cases with glaucoma and pseudoexfoliation were compared with the control group. Ophthalmic artery colour Doppler imaging measurements were performed in all patients. Also, peripapillary RNFL analysis was performed. ResultsA statistically significant difference was found between the total RNFL measurements according to group (p = 0.012; p < 0.05). From the paired comparisons, the total RNFL measurements from the control group were higher than the group without glaucoma (p = 0.010). No statistically significant difference was found between the total RNFL measurements of the other groups (p > 0.05). In the pseudoexfoliative glaucoma (PXG) group, there was a statistically significant negative correlation between total RNLF and Peak systolic velocity (PSV) (r = -0.743; p < 0.01). There was also a statistically significant negative correlation between total RNLF and End diastolic velocity (EDV) (r = -0.691; p < 0.01). There was no significant relationship between total RNLF and resistive index (RI) measurements (p > 0.05). ConclusionPseudoexfoliation syndrome(PXS) caused a decrease in the PSV and EDV values of ophthalmic artery blood flow parameters. Again, PXS caused a decrease in total RNFL, RNFL S, RNFL I and RNFL T thickness values.