Nature Cancer | 2021

Patterns of seroconversion for SARS-CoV-2 IgG in patients with malignant disease and association with anticancer therapy

 
 
 
 
 
 
 
 
 
 
 
 
 

Abstract


1Division of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, The Bronx, NY, USA. 2Department of Epidemiology and Population Health, Albert Einstein College of Medicine, The Bronx, NY, USA. 3Department of Internal Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, The Bronx, NY, USA. 4Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, The Bronx, NY, USA. ✉e-mail: [email protected]; [email protected] The coronavirus pandemic that started in December 2019 in Wuhan, China continues to send waves of COVID-19 disease throughout the world1,2. Several observational studies have identified patients with cancer as being at higher risk of contracting the virus with higher rates of manifesting a severe form of COVID19 disease3–5. We have previously reported a higher case fatality rate in patients with hematological malignancies compared to solid malignancies in patients with cancer6. A pooled meta-analysis of 52 studies involving patients with cancer and COVID-19 reported a mortality rate of 25.6%7. While the mortality rates of patients with cancer are higher than the general population, it seems that about 70–80% of patients with cancer survive COVID-19 and therefore, it is important to understand the natural history of COVID-19 in this high-risk patient population. Of particular importance is the fact that this patient population often receives immunosuppressive cancer-directed therapy, which may impact their ability to mount a humoral immune response to the virus. It is therefore prudent to study the rate of formation of such antibodies to SARS-CoV-2 in patients with cancer who survived the illness to properly inform and develop treatment, surveillance and monitoring strategies in this vulnerable patient population.

Volume None
Pages None
DOI 10.21203/rs.3.rs-127470/v1
Language English
Journal Nature Cancer

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