Clinical And Epidemiologic Profile of Breast Cancer Differences In Mexico: A Retrospective Cohort Study From Guerrero.

Abstract

\n Background: The regional disparities in Mexico impact the incidence and mortality of breast cancer (BC). Despite Guerrero state has a high grade of economic marginalization, it presents mortality lower than the national average. Clinical, pathological, and epidemiological assessment will help to understand the source of these differences.Objective: Describe the clinical, pathological, and overall survival of patients with BC from Guerrero and compare them with other reports from the Mexican population.Materials and Methods: Kaplan-Meier method was used to estimate overall survival time over a retrospective cohort of breast cancer patients treated at the Instituto Estatal de Cancerología “Dr. Arturo Beltrán Ortega (IECan) during 2010-2020. The Cox proportional hazards model was used to determine the prognosis factors.Results: A total of 923 women were included. 3.5% and 37.9% of patients were classified as Stage I and II; for locally advanced stages III and IV, it has been observed 36.1% and 14.3% of patients respectively. The most frequent histological type was ductal carcinoma (82.7%). The molecular subtype percentage found were HR+/HER2- (35.1%), HR±/HER2- (15.9%), HR±/HER2+ (14.4%), HR-/HER2+ (13.5%) and HR-/HER2 - (21%). The median follow-up was 49 months. Five-year survival for the entire cohort was 78% (95% CI, 73-82%), and 31% for metastatic disease (95% CI, 26.7-37.1%).Conclusion: The Guerrero state shares epidemiological parameters with other regions of Mexico; despite this, presents frequently one of the most aggressive molecular subtypes of breast cancer; so, the understanding of its lower mortality requires further analysis.