Archive | 2021
Statin in Combined With Xuezhikang Capsules Get More Lipid-Regulating Effective Than Statin Only: A Systematic Review and Meta-Analysis
Abstract
\n Background: To compare the lipid-regulating effects and safety of statin combined with Xuezhikang capsules and statin used alone for hyperlipidemia. Methods: CNKI, Wanfang database, VIP Chinese Journals, PubMed, Embase, and Cochrane library were searched to comprehensively collect and screen RCTs of Xuezhikang combined with statin compared with statin used alone for lipid modifying treatment in hyperlipidemia patients from the database built as of July 2020, and the Cochrane 5.1.0 quality evaluation form was used to evaluate the quality of the included literature and The Cochrane 5.1.0 quality assessment form was used to evaluate the quality of the included literature and bias analysis, extract basic study information, primary and secondary outcome indicators, and meta-analysis of the outcome indicators was performed using RevMan 5.3. Results: A total of 14 studies with a total of 2042 patients were included, and the quality of the included studies was low to medium. ①Effectiveness rate: OR=3.63,95%CI[2.69,4.90],P<0.00001; Funnel plot: all within the funnel, but not in accordance with the principle of aggregation at the top and dispersion at the bottom . ②Total cholesterol: MD=-0.61,95%CI[-0.84,-0.39],P<0.00001, The forest plots of each subgroup are to the left, P<0.05. ③Triglycerides: MD=-0.30,95%CI[-0.41,-0.19],P<0.00001, The forest plots of each subgroup are to the left, P<0.05. 0.05. ④ LDL: MD=-0.33,95%CI[-0.46,-0.20],P<0.00001, The forest plots of each subgroup are to the left, P<0.05 in atorvastatin and fluvastatin groups, P=0.09 in simvastatin group. ⑤ HDL: MD=0.23, 95%CI [0.12,0.35], P<0.00001, The forest plots of each subgroup are to the right, P<0.05. 6) Adverse effects: OR=0.32, 95% CI[0.19,0.55],P<0.0001. Conclusion: The combination of statin with Xuezhikang capsule has better effect on lipid regulation in patients with hyperlipidemia, and can effectively reduce the incidence of adverse events and has better safety. It is recommended that the treatment of Xuezhikang combined with statin can be used as a safer and more effective treatment for patients with hyperlipidemia.